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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
35.45
Human Site:
S707
Identified Species:
55.71
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
S707
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Chimpanzee
Pan troglodytes
XP_528129
863
96543
S707
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
S773
P
R
L
S
Q
E
A
S
Q
A
L
I
E
A
Y
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
S706
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Rat
Rattus norvegicus
NP_387500
862
96552
S706
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
S707
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Chicken
Gallus gallus
XP_424376
859
96866
S703
P
R
L
S
E
E
A
S
Q
A
L
I
Q
A
Y
Frog
Xenopus laevis
P30664
863
97105
S707
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
N607
N
P
V
E
S
Q
W
N
P
K
K
T
T
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Q709
P
T
L
S
D
E
A
Q
Q
R
L
I
Q
A
Y
Honey Bee
Apis mellifera
XP_624670
636
71159
F493
K
G
I
I
L
Q
L
F
G
G
T
R
K
A
S
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
A616
M
R
N
P
V
V
N
A
D
A
F
K
S
G
K
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
S754
P
N
L
G
D
E
A
S
Q
L
L
I
Q
A
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
E573
P
Y
V
P
A
E
L
E
E
Y
I
A
T
A
Y
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
V771
E
A
A
K
T
E
L
V
R
A
Y
V
G
M
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
100
93.3
100
0
N.A.
66.6
6.6
13.3
66.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
20
N.A.
80
26.6
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
7
0
67
7
0
67
0
7
0
80
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
14
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
7
0
0
7
47
80
0
7
7
0
0
0
47
0
7
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% F
% Gly:
0
7
0
7
0
0
0
0
7
7
0
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
0
0
0
0
0
0
7
67
0
7
0
% I
% Lys:
7
0
0
7
0
0
0
0
0
7
7
7
7
0
7
% K
% Leu:
0
0
67
0
7
0
20
0
0
7
67
0
0
0
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
7
7
7
0
0
0
7
7
0
0
0
0
0
0
0
% N
% Pro:
74
7
0
14
0
0
0
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
14
0
7
67
0
0
0
20
0
0
% Q
% Arg:
0
60
0
0
0
0
0
0
7
7
0
7
0
0
7
% R
% Ser:
0
0
0
60
7
0
0
60
0
0
0
0
7
0
7
% S
% Thr:
0
7
0
0
7
0
0
0
0
0
7
7
14
0
0
% T
% Val:
0
0
14
0
7
7
0
7
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
7
7
0
0
0
74
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _